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[载脂蛋白B基因限制性片段长度多态性与缺血性心脏病患者血脂谱的关系]

[The relationship of the restriction fragment length polymorphism of the apo-B gene to the blood lipid spectrum in patients with ischemic heart disease].

作者信息

Tseluĭko V I, Kravchenko N A, Shut' I V, Cherkashina V I

出版信息

Tsitol Genet. 1994 Sep-Oct;28(5):73-7.

PMID:7900201
Abstract

Restriction fragment length polymorphism of the apo-B gene at the Xbal restriction site was detected. The association between RFLP of the apo-B gene and the level of lipid metabolism indices was revealed. The levels of total cholesterol LDLP CH and atherogenicity coefficient were significantly higher in homozygotes with this restriction site (X2X2) than in homozygotes X1X1 and heterozygotes.

摘要

检测到载脂蛋白B基因在XbaI酶切位点的限制性片段长度多态性。揭示了载脂蛋白B基因的限制性片段长度多态性与脂质代谢指标水平之间的关联。具有该酶切位点的纯合子（X2X2）的总胆固醇、低密度脂蛋白胆固醇和致动脉粥样硬化系数水平显著高于纯合子X1X1和杂合子。

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