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[10年观察期内聚腺嘌呤-聚尿嘧啶制剂对恶性黑色素瘤患者的辅助治疗结果]

[Results of adjuvant therapy with the preparation Poly-a Poly-u in patients with malignant melanoma during a 10-year observation].

作者信息

Pawlicki M, Jońca M, Krzemieniecki K, Zuchowska-Vogelgesang B

机构信息

Kliniki Chemioterapii Instytutu Onkologii w Krakowie.

出版信息

Wiad Lek. 1993 Dec;46(23-24):912-4.

PMID:7900387
Abstract

During 10 years patients with malignant melanoma were followed up after radical removal of primary tumour and metastatic regional lymph nodes, the half of whom was given immunomodulation with the preparation Poly-A Poly-U in a controlled clinical trial. It was found that the performed immunomodulation exerted slight effect on the course of malignant melanoma causing later development of recurrence, less dynamic course of the disease, longer asymptomatic periods in relation to the control group. No effect of the drug administration was observed on longterm survival.

摘要

在10年期间,对原发性肿瘤和转移性区域淋巴结进行根治性切除后的恶性黑色素瘤患者进行了随访,其中一半患者在一项对照临床试验中接受了聚肌胞苷酸(Poly-A Poly-U)制剂的免疫调节治疗。结果发现,所进行的免疫调节对恶性黑色素瘤的病程产生了轻微影响,导致复发较晚出现、疾病进展较缓慢、与对照组相比无症状期更长。未观察到给药对长期生存有影响。

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