Zhang T M, Yang Z Q, Zhang M Y, Hu Z J, Xiang J M, Huggins J W, Cosgriff T M, Smith J I
Virus Research Institute, Hubei Medical College, Wuhan.
Chin Med J (Engl). 1993 Aug;106(8):608-10.
We analysed the early viremia and clinical tests in 82 patients with epidemic hemorrhagic fever (EHF). The results showed that the changes in viremia and clinical tests are related to the severity of the disease and prognosis. Higher concentrations of the virus in infected patients might cause a more unfavourable prognosis and more abnormalities in clinical tests. CK-MB, SGOT, SGPT, serum creatinine and urea nitrogen contents increased markedly, while serum total protein, albumin and calcium contents decreased markedly, indicating that the heart, liver and kidney in EHF patients were severely damaged. Markedly increased WBC and monocytes showed that the patients were seriously infected. Platelet count, antithrombin-III and plasminogen decreased markedly, demonstrating that there were marked changes in the coagulation-anticoagulation and fibrinolytic system of the EHF patients. Changes in RBC, Hb and HCT contents indicated that the blood in the EHF patients had a higher concentration. This study gives further evidence that EHFV plays an important role in the pathogenesis of EHF.
我们分析了82例流行性出血热（EHF）患者的早期病毒血症及临床检验情况。结果显示，病毒血症及临床检验的变化与疾病严重程度及预后相关。感染患者体内病毒浓度越高，预后可能越差，临床检验异常也越多。肌酸激酶同工酶（CK-MB）、谷草转氨酶（SGOT）、谷丙转氨酶（SGPT）、血清肌酐及尿素氮含量显著升高，而血清总蛋白、白蛋白及钙含量显著降低，表明EHF患者的心脏、肝脏及肾脏受到严重损害。白细胞及单核细胞显著增多表明患者受到严重感染。血小板计数、抗凝血酶III及纤溶酶原显著降低，表明EHF患者的凝血-抗凝及纤溶系统发生了显著变化。红细胞、血红蛋白及血细胞比容含量的变化表明EHF患者血液浓度较高。本研究进一步证明汉坦病毒（EHFV）在EHF发病机制中起重要作用。
