Chishiro T, Tanaka T
Kansai Medical University, Osaka, Japan.
Vet Hum Toxicol. 1988 Feb;30(1):1-4.
Elevation of serum creatine phosphokinase (CPK), known to occur in only cerebral, cardiac and muscular diseases, was encountered in 34 patients with drug intoxication. The mechanism of hyper-CPKemia in drug intoxication was examined by determining the correlations between CPK variations and underlying factors. Liver function, WBC, serum total protein, albumin and blood sugar indicated correlations with serum CPK. It seemed that increased blood sugar, decreased protein, decreased albumin and increased WBC were associated with hyper-CPKemia and reflected severe acute stress to the nervous, endocrine and metabolic systems collapsing the systemic physiological homeostasis.
血清肌酸磷酸激酶（CPK）升高仅见于脑部、心脏和肌肉疾病，在34例药物中毒患者中也有发现。通过确定CPK变化与潜在因素之间的相关性，研究了药物中毒时高CPK血症的机制。肝功能、白细胞、血清总蛋白、白蛋白和血糖与血清CPK存在相关性。似乎血糖升高、蛋白质降低、白蛋白降低和白细胞增加与高CPK血症有关，反映了对神经、内分泌和代谢系统的严重急性应激，破坏了全身生理稳态。
