Montes B, Catalan M, Roces A, Jeanniot J P, Honorato J M
Servicio de Farmacologia Clinica, Universidad de Navarra, Pampelona, Spain.
Eur J Clin Pharmacol. 1993;45(2):169-72. doi: 10.1007/BF00315501.
The absolute bioavailability of fenspiride has been studied in twelve healthy volunteers. It was administered IV and orally in single doses of 80 mg fenspiride hydrochloride according to a randomised crossover pattern. Following IV administration, the plasma clearance of fenspiride was about 184 ml.min-1, and its apparent volume of distribution was moderately large (215 l). When given orally as a tablet, fenspiride exhibited fairly slow ab- sorption; the maximum plasma concentration (206 ng.ml-1) was achieved 6 h after administration. The absolute bioavailability was almost complete (90%). The tablet had slow release characteristics. The elimination half-life obtained from the plasma data was 14 to 16 h independent of the route of administration.
已在12名健康志愿者中研究了喷司哌啶的绝对生物利用度。按照随机交叉模式，静脉注射和口服单剂量80mg盐酸喷司哌啶。静脉注射后，喷司哌啶的血浆清除率约为184ml.min-1，其表观分布容积中等偏大（215L）。当以片剂形式口服时，喷司哌啶吸收相当缓慢；给药后6小时达到最大血浆浓度（206ng.ml-1）。绝对生物利用度几乎完全（90%）。该片剂具有缓释特性。从血浆数据获得的消除半衰期为14至16小时，与给药途径无关。
