Weiner D L
Methods Find Exp Clin Pharmacol. 1986 Oct;8(10):625-8.
A new software package, NONLIN84, has been developed for the analysis of general nonlinear models including pharmacokinetic models. NONLIN84 is easier to use than the older NONLIN77, and can handle a wider class of estimation problems, such as maximum likelihood estimation involving iterative reweighting. Two large libraries of pharmacokinetic models are distributed with NONLIN84 and can be accessed by simply specifying a model number. A companion program, PCNONLIN, runs on DOS based microcomputers and retains most of the features of NONLIN84.
已开发出一个名为NONLIN84的新软件包，用于分析包括药代动力学模型在内的一般非线性模型。NONLIN84比旧版的NONLIN77更易于使用，并且能够处理更广泛的一类估计问题，例如涉及迭代加权的最大似然估计。NONLIN84附带了两个大型药代动力学模型库，只需指定模型编号即可访问。一个配套程序PCNONLIN可在基于DOS的微型计算机上运行，并保留了NONLIN84的大部分功能。
