Kojima T, Sone M, Michiue T, Saigo K
Department of Biophysics and Biochemistry, School of Science, University of Tokyo, Japan.
Genetica. 1993;88(2-3):85-91. doi: 10.1007/BF02424465.
The Bar locus of Drosophila is known to be a small complex consisting of two similar homeobox genes, BarH1 and BarH2. Using egr as an ommatidium marker, possible mechanisms of formation of malformed eyes were examined. As in the case of BarH1, overexpression of BarH2 was found to be capable of inducing Bar-like eye malformation. It was suggested that suppression of the anterior progression of the morphogenetic furrow and inhibition of reinitiation of normal ommatidial differentiation were mandatory to formation of the reduced eye morphology in Bar mutants.
已知果蝇的棒眼基因座是一个由两个相似的同源异型盒基因BarH1和BarH2组成的小复合体。以egr作为小眼标记，研究了形成畸形眼的可能机制。与BarH1的情况一样，发现BarH2的过表达能够诱导棒状眼畸形。有人提出，抑制形态发生沟的向前推进以及抑制正常小眼分化的重新启动是Bar突变体中形成小眼形态减少的必要条件。
