Salter-Cid L, Kasahara M, Flajnik M F
Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101.
Immunogenetics. 1994;39(1):1-7. doi: 10.1007/BF00171790.
Some of the inducible forms of the heat shock protein 70 (Hsp70) gene family are encoded in the class III region of the major histocompatibility complex (MHC) of mammals. This study was undertaken to determine whether Hsp70 genes are linked to the MHC of Xenopus, an amphibian last sharing a common ancestor with mammals 300-350 million years ago. Segregation analyses involving seven haplotypes demonstrated the linkage of two or three inducible Hsp70 genes to the frog MHC. Another Hsp70 gene is not closely linked to the MHC. We conclude that the physical association of MHC class I and class II genes with Hsp70 genes is ancient.
热休克蛋白70（Hsp70）基因家族的一些可诱导形式编码于哺乳动物主要组织相容性复合体（MHC）的Ⅲ类区域。本研究旨在确定Hsp70基因是否与非洲爪蟾的MHC相关联，非洲爪蟾是一种两栖动物，在3亿至3.5亿年前与哺乳动物拥有共同的祖先。涉及7种单倍型的分离分析表明，两到三个可诱导的Hsp70基因与蛙类MHC存在连锁关系。另一个Hsp70基因与MHC没有紧密连锁。我们得出结论，MHC Ⅰ类和Ⅱ类基因与Hsp70基因的物理关联由来已久。
