Perry K W, Fuller R W
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285.
J Pharm Pharmacol. 1993 Aug;45(8):759-61. doi: 10.1111/j.2042-7158.1993.tb07105.x.
Fluoxetine (10 mg kg-1, i.p.) caused a three- to fourfold increase in extracellular 5-hydroxytryptamine (5-HT) concentration measured by microdialysis in hypothalamus of freely moving rats. The addition of L-5-hydroxytryptophan at 20 or 40 mg kg-1, i.p. doses, magnified the increase in extracellular 5-HT to as much as 16 times basal levels, although these doses of L-5-hydroxytryptophan alone had only small effects on extracellular 5-HT. The increased formation of 5-HT following L-5-hydroxytryptophan administration appears to overcome homeostatic mechanisms that limit the increases in extracellular 5-HT caused by uptake inhibition.
氟西汀（10毫克/千克，腹腔注射）使自由活动大鼠下丘脑通过微透析测量的细胞外5-羟色胺（5-HT）浓度增加了三到四倍。腹腔注射20或40毫克/千克剂量的L-5-羟色氨酸，可将细胞外5-HT的增加放大至基础水平的16倍，尽管这些剂量的L-5-羟色氨酸单独对细胞外5-HT仅有微小影响。给予L-5-羟色氨酸后5-HT形成的增加似乎克服了限制因摄取抑制导致的细胞外5-HT增加的稳态机制。
