Pöllänen P, von Euler M, Jahnukainen K, Saari T, Parvinen M, Sainio-Pöllänen S, Söder O
Department of Anatomy, University of Turku, Finland.
J Reprod Immunol. 1993 Jul;24(2):123-37. doi: 10.1016/0165-0378(93)90015-a.
The potential role of transforming growth factor beta (TGF beta) in the regulation of the immunological milieu of the testis was investigated. Antibodies neutralizing TGF beta reversed the previously observed suppression of rat peripheral blood lymphocyte proliferation induced by rat abdominal testis extract. Recombinant TGF beta 1 dose-dependently inhibited testicular interleukin-1-like factor-driven proliferation of murine thymocytes and ConA-stimulated rat peripheral blood mononuclear cells. Extracts of seminiferous tubules contained a M(r) approximately 25 K TGF beta-like growth inhibitor of the CLL-64 mink lung epithelial cell line. The present findings suggest an important role for TGF beta in testicular immunosuppression.
研究了转化生长因子β（TGF-β）在调节睾丸免疫微环境中的潜在作用。中和TGF-β的抗体逆转了先前观察到的大鼠腹腔睾丸提取物诱导的大鼠外周血淋巴细胞增殖抑制。重组TGF-β1剂量依赖性地抑制睾丸白细胞介素-1样因子驱动的小鼠胸腺细胞增殖和刀豆蛋白A刺激的大鼠外周血单个核细胞增殖。生精小管提取物含有一种分子量约为25K的CLL-64貂肺上皮细胞系的TGF-β样生长抑制剂。目前的研究结果表明TGF-β在睾丸免疫抑制中起重要作用。
