Nakamura T, Ebihara I, Shirato I, Fukui M, Tomino Y, Koide H
Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Lancet. 1993 Nov 6;342(8880):1147-8. doi: 10.1016/0140-6736(93)92126-e.
We investigated endothelin-1 mRNA expression in peripheral blood monocytes from 40 patients with IgA nephropathy, 40 with other glomerulonephritides and 10 with essential hypertension without renal diseases, and from 30 healthy age-matched controls. 95% of patients with IgA nephropathy had increased endothelin-1 mRNA expression in monocytes but little was detected from the other groups. Endothelin-1 mRNA was positively correlated with urinary protein excretion (95% CI 0.835-0.952) and histopathological findings (0.796-0.939). In 15 patients with IgA nephropathy endothelin-1 mRNA values and proteinuria decreased gradually after treatment. Endothelin-1 mRNA-expressing activated monocytes may be associated with the progression of IgA nephropathy.
我们研究了40例IgA肾病患者、40例其他肾小球肾炎患者、10例无肾脏疾病的原发性高血压患者以及30例年龄匹配的健康对照者外周血单核细胞中内皮素-1 mRNA的表达情况。95%的IgA肾病患者单核细胞中内皮素-1 mRNA表达增加，而其他组检测到的表达很少。内皮素-1 mRNA与尿蛋白排泄（95%可信区间0.835 - 0.952）及组织病理学结果（0.796 - 0.939）呈正相关。15例IgA肾病患者治疗后内皮素-1 mRNA值及蛋白尿逐渐下降。表达内皮素-1 mRNA的活化单核细胞可能与IgA肾病的进展有关。
