Chase T N, Shoulson I, Carter A C
Monogr Neural Sci. 1976;3:8-14. doi: 10.1159/000399327.
Abundant preclinical evidence suggests that serotonin-containing neural systems may participate in the regulation of both extrapyramidal and neuroendocrine function. In an attempt to examine these possibilities in man, patients with various neurologic disorders received drugs believed to facilitate or inhibit serotonergic function. Extrapyramidal signs in patients with parkinsonism or Huntington's disease showed no consistent change with L-tryptophan or parachlorophenylalanine. Unexpectedly, L-5-hydroxytryptophan, given in combination with a peripheral decarboxylase inhibitor, caused a worsening of parkinsonian akinesia and rigidity. Fenfluramine, at doses which appeared to diminish central serotonin but not dopamine turnover, had no consistent effect on the severity of involuntary movements in patients with Huntington's chorea, but did produce a significant rise in plasma prolactin.
大量临床前证据表明，含血清素的神经系统可能参与锥体外系和神经内分泌功能的调节。为了在人体中研究这些可能性，患有各种神经系统疾病的患者接受了据信可促进或抑制血清素能功能的药物。帕金森病或亨廷顿病患者的锥体外系体征在使用L-色氨酸或对氯苯丙氨酸后未显示出一致的变化。出乎意料的是，L-5-羟色氨酸与外周脱羧酶抑制剂联合使用会导致帕金森病运动不能和僵硬加重。氟苯丙胺在似乎可减少中枢血清素但不影响多巴胺代谢的剂量下，对亨廷顿舞蹈病患者不自主运动的严重程度没有一致影响，但确实使血浆催乳素显著升高。
