Bench C J, Friston K J, Brown R G, Frackowiak R S, Dolan R J
Academic Department of Psychiatry, Royal Free Hospital School of Medicine, London.
Psychol Med. 1993 Aug;23(3):579-90. doi: 10.1017/s0033291700025368.
We have previously reported focal abnormalities of regional cerebral blood flow (rCBF) in a group of 33 patients with major depression. This report, on an extended sample of 40 patients who demonstrated identical regional deficits to those previously described, examines the relationships between depressive symptoms and patterns of rCBF. Patients' symptom ratings were subjected to factor analysis, producing a three-factor solution. The scores for these three factors, which corresponded to recognizable dimensions of depressive illness, were then correlated with rCBF. The first factor had high loadings for anxiety and correlated positively with rCBF in the posterior cingulate cortex and inferior parietal lobule bilaterally. The second factor had high loadings for psychomotor retardation and depressed mood and correlated negatively with rCBF in the left dorsolateral prefrontal cortex and left angular gyrus. The third factor had a high loading for cognitive performance and correlated positively with rCBF in the left medial prefrontal cortex. These data indicate that symptomatic specificity may be ascribed to regional functional deficits in major depressive illness.
我们之前报道过一组33例重度抑郁症患者存在局部脑血流（rCBF）异常。本报告基于40例患者的扩大样本，这些患者表现出与之前描述相同的局部缺损，研究了抑郁症状与rCBF模式之间的关系。对患者的症状评分进行因子分析，得出一个三因子解决方案。这三个因子的得分对应于抑郁症可识别的维度，然后将其与rCBF进行相关性分析。第一个因子在焦虑方面有高负荷，与双侧后扣带回皮质和顶下小叶的rCBF呈正相关。第二个因子在精神运动迟缓及情绪低落方面有高负荷，与左侧背外侧前额叶皮质和左侧角回的rCBF呈负相关。第三个因子在认知表现方面有高负荷，与左侧内侧前额叶皮质的rCBF呈正相关。这些数据表明，重度抑郁症的症状特异性可能归因于局部功能缺损。
