经颅直流电刺激对重度抑郁症精神运动症状的影响。
Influence of Transcranial Direct Current Stimulation on Psychomotor Symptoms in Major Depression.
作者信息
Bennabi Djamila, Carvalho Nicolas, Bisio Ambra, Teti Mayer Juliana, Pozzo Thierry, Haffen Emmanuel
机构信息
Service de Psychiatrie de l'Adulte, Centre Hospitalier Universitaire de Besançon, 25030 Besançon CEDEX, France.
Centre Expert Dépression Résistante FondaMental, Centre Hospitalier Universitaire de Besançon, 25030 Besançon CEDEX, France.
出版信息
Brain Sci. 2020 Oct 29;10(11):792. doi: 10.3390/brainsci10110792.
BACKGROUND
Transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex (dlPFC) might be a promising treatment strategy for depression. As disturbances in psychomotor activity are one of the key features of unipolar depression are, we aimed to evaluate the behavioral effects of ten tDCS sessions over a 5-day period on psychomotor retardation in depressed patients.
METHODS
Twenty-three treatment-resistant depressed patients received either active or sham anodal tDCS to the left dorsolateral prefrontal cortex (2 mA, 10 sessions over 1 week). Psychomotor functioning was registered by means of observer ratings (Salpêtrière Retardation Rating Scale-SRRS) and objective measures (kinematical analysis of movements, automatic imitation).
RESULTS
tDCS sessions resulted in improvements on SRRS scores, although active tDCS was not significantly superior to sham tDCS on the kinematical parameters. Furthermore, no general additional antidepressant effect of tDCS was observed. The relatively small sample size and the short periods of observation should be considered when interpreting these results.
CONCLUSION
tDCS did not induce a clinically relevant effect on psychomotor function in active and sham stimulation groups.
背景
经颅直流电刺激（tDCS）作用于左侧背外侧前额叶皮质（dlPFC）可能是一种有前景的抑郁症治疗策略。由于精神运动活动障碍是单相抑郁症的关键特征之一，我们旨在评估在5天内进行10次tDCS治疗对抑郁症患者精神运动迟缓的行为学影响。
方法
23例难治性抑郁症患者接受了左侧背外侧前额叶皮质的阳极tDCS治疗（2毫安，1周内进行10次），治疗方式为主动或假刺激。通过观察者评分（萨尔佩特里埃迟缓评定量表-SRRS）和客观测量（运动学分析、自动模仿）来记录精神运动功能。
结果
tDCS治疗使SRRS评分有所改善，尽管在运动学参数方面，主动tDCS并不显著优于假tDCS。此外，未观察到tDCS具有普遍的额外抗抑郁作用。在解释这些结果时应考虑样本量相对较小和观察期较短的因素。
结论
在主动刺激组和假刺激组中，tDCS对精神运动功能均未产生临床相关影响。
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