Bax D E, Amos R S
Ann Rheum Dis. 1986 Feb;45(2):139-40. doi: 10.1136/ard.45.2.139.
Sulphasalazine has been shown to be useful in the management of rheumatoid arthritis. However, its use may be complicated by a skin rash. Eight patients with a rash have undergone desensitisation, the aim of which was to achieve a daily dose of 2 g sulphasalazine. This was successful in five patients, partially successful in two, and failed in one patient. Desensitisation to sulphasalazine is a simple outpatient procedure, which subsequently allows the majority of patients developing a skin rash to continue treatment.
柳氮磺胺吡啶已被证明在类风湿性关节炎的治疗中有用。然而,其使用可能会因皮疹而变得复杂。八名出现皮疹的患者接受了脱敏治疗,目的是达到每日2克柳氮磺胺吡啶的剂量。五名患者成功,两名部分成功,一名患者失败。柳氮磺胺吡啶脱敏是一种简单的门诊程序,随后可使大多数出现皮疹的患者继续治疗。