Shijubo N, Imai K, Nakanishi F, Yachi A, Abe S
Department of Internal Medicine, Sapporo Medical University, Japan.
Am Rev Respir Dis. 1993 Nov;148(5):1298-301. doi: 10.1164/ajrccm/148.5.1298.
Intercellular adhesion molecule-1 (ICAM-1) plays an important role in inflammatory diseases. Cellular expression and shedding of ICAM-1 are up-regulated by cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). With an ELISA containing two monoclonal antibodies to human ICAM-1, we measured concentrations of circulating ICAM-1 in patients with tuberculosis. Prominently elevated values were found in miliary tuberculosis and in far advanced pulmonary tuberculosis but not in minimal or moderately advanced disease. The measurement of serum IFN-gamma and TNF-alpha also revealed high concentrations of the cytokines in miliary tuberculosis and far advanced pulmonary tuberculosis. The circulating ICAM-1 values were significantly correlated to serum IFN-gamma and TNF-alpha values. In the case of miliary tuberculosis and far advanced pulmonary tuberculosis treated with antituberculous drugs, the circulating ICAM-1 concentrations were gradually decreased to correspond with improvement of clinical symptoms and chest X-ray findings. The measurement of circulating ICAM-1 is useful to evaluate the severity of tuberculosis and to monitor disease activity during antituberculous drug treatment.
细胞间黏附分子-1（ICAM-1）在炎症性疾病中起重要作用。ICAM-1的细胞表达和脱落受细胞因子如肿瘤坏死因子-α（TNF-α）和干扰素-γ（IFN-γ）的上调。我们使用一种含有两种抗人ICAM-1单克隆抗体的酶联免疫吸附测定（ELISA）法，测量了结核病患者循环中ICAM-1的浓度。在粟粒性肺结核和晚期肺结核患者中发现其值显著升高，但在轻度或中度进展期疾病中未发现升高。血清IFN-γ和TNF-α的测量也显示粟粒性肺结核和晚期肺结核患者中细胞因子浓度较高。循环ICAM-1值与血清IFN-γ和TNF-α值显著相关。在接受抗结核药物治疗的粟粒性肺结核和晚期肺结核患者中，循环ICAM-1浓度逐渐下降，与临床症状和胸部X线表现的改善相对应。循环ICAM-1的测量有助于评估结核病的严重程度，并在抗结核药物治疗期间监测疾病活动。
