Shijubo N, Hirasawa M, Inuzuka M, Asakawa M, Abe S, Imai K
Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan.
Kekkaku. 1994 Jul;69(7):471-4.
Intercellular adhesion molecule 1 (ICAM-1) plays an important role in inflammatory diseases. We investigated levels of circulating soluble ICAM-1 in patients with miliary tuberculosis (n = 8) and pulmonary tuberculosis (n = 49). We also attempted to compare ICAM-1 levels among pulmonary tuberculosis patients according to chest X ray classification of the Japanese Society for Tuberculosis. Significantly increased levels of circulating ICAM-1 were found in patients with miliary tuberculosis and extensive (extent 3) pulmonary tuberculosis (n = 9) compared to those of controls (n = 48), but not in patients with extent 1 (n = 24) or extent 2 pulmonary tuberculosis (n = 16). Immunohistochemical examination of the tuberculous lung tissues from the patients showed intensive cellular ICAM-1 on epithelioid cells and giant cells as well as on vascular endothelial cells. These results suggest that ICAM-1 is an important adhesion molecule in tuberculosis.
细胞间黏附分子1（ICAM-1）在炎症性疾病中起重要作用。我们调查了粟粒型肺结核患者（n = 8）和肺结核患者（n = 49）循环可溶性ICAM-1的水平。我们还试图根据日本结核病学会的胸部X线分类比较肺结核患者之间的ICAM-1水平。与对照组（n = 48）相比，粟粒型肺结核患者和广泛型（3型）肺结核患者（n = 9）循环ICAM-1水平显著升高，但1型（n = 24）或2型肺结核患者中未升高。对患者结核肺组织的免疫组织化学检查显示，上皮样细胞、巨细胞以及血管内皮细胞上有密集的细胞ICAM-1。这些结果表明，ICAM-1是结核病中的一种重要黏附分子。
