Kling A S, Tachiki K, Lloyd R
Psychiatry Service, Veterans Affairs Medical Center, Sepulveda, CA 91343.
Behav Brain Res. 1993 Sep 30;56(2):161-70. doi: 10.1016/0166-4328(93)90034-n.
The Klüver-Bucy syndrome is a well known consequence of lesions of the temporal lobe, but the neural mechanisms remain obscure. To elucidate the neurochemical changes in this syndrome, we utilized in vivo microdialysis of amygdala and hypothalamus in two Cebus monkeys (C. apella) before and after bilateral lesions of the temporal pole (TP). Both subjects were housed and observed in a social group when not being dialyzed. Behavioral changes consequent to the TP lesion included early postoperative anorexia, adipsia, hunched posture, tameness, and lethargy. Subsequently loss of fear, hyperorality, loss of social rank, and social withdrawal were observed. Neurochemical changes in amygdala included fall in DA metabolites, increase in NE, and fall in 5-HIAA. The amino acids glutamate and aspartate were both lower postoperatively but more so in the subject with the greatest behavioral changes. Similar changes were noted in hypothalamus except for DA metabolites which remained unchanged. The Klüver-Bucy syndrome consequent to ablation of the temporal pole appears related to a partial deafferentation of excitatory projections to amygdala, along with a lowering of DA and 5-HIAA and an increase in NE.
克吕弗-布西综合征是颞叶损伤的一个众所周知的后果，但其神经机制仍不清楚。为了阐明该综合征中的神经化学变化，我们在两只僧帽猴（C. apella）双侧颞极（TP）损伤前后，对杏仁核和下丘脑进行了体内微透析。在不进行透析时，两只动物都饲养在一个社会群体中并接受观察。TP损伤导致的行为变化包括术后早期厌食、拒饮、弓背姿势、温顺和嗜睡。随后观察到恐惧丧失、口欲亢进、社会等级丧失和社交退缩。杏仁核中的神经化学变化包括多巴胺（DA）代谢产物减少、去甲肾上腺素（NE）增加和5-羟吲哚乙酸（5-HIAA）减少。谷氨酸和天冬氨酸这两种氨基酸在术后均降低，但在行为变化最大的动物中降低得更多。下丘脑也观察到类似变化，但DA代谢产物保持不变。颞极切除导致的克吕弗-布西综合征似乎与杏仁核兴奋性投射的部分传入缺失有关，同时伴有DA和5-HIAA降低以及NE增加。
