Peszkowski M J, Warfvinge G, Larsson A
Department of Oral Pathology, Lund University, Malmö, Sweden.
Clin Immunol Immunopathol. 1993 Dec;69(3):272-7. doi: 10.1006/clin.1993.1180.
Low doses of HgCl2 induce a genetically restricted autoimmune syndrome in Brown Norway (BN) rats (BN(Hg)). Part of the syndrome includes spontaneously developing mononuclear cell foci in salivary and lacrimal glands, morphologically similar to focal sialoadenitis in Sjögren's syndrome in man. In this study, we have shown that Hg-induced focal adenitis in BN rat is not female predominant and not solely dependent on Hg uptake in the glands. In BN(Hg), focal adenitis was found to develop in several different glands (parotid, submandibular, lacrimal, thyroid) as a specific manifestation of immunopathosis induced by Hg in the RT1n-haplotype-carrying BN. Such manifestations were absent in another strain, the Hg-resistant Lewis (RT1l). Also a potent contact sensitizer, DNFB, induced focal adenitis in isolated glands, provided that strong sensitization had occurred. Immunohistochemical characterization of focal adenitis in BN(Hg) with monoclonal antibodies showed that T cells and dendritic cells dominate the early infiltrates, whereas B cells were absent.
低剂量的氯化汞会在棕色挪威（BN）大鼠中诱发一种基因受限的自身免疫综合征（BN（Hg））。该综合征的部分症状包括唾液腺和泪腺中自发形成单核细胞灶，形态上类似于人类干燥综合征中的局灶性涎腺炎。在本研究中，我们发现汞诱导的BN大鼠局灶性腺炎并非以雌性为主，也并非仅依赖于腺体对汞的摄取。在BN（Hg）中，局灶性腺炎在几个不同的腺体（腮腺、下颌下腺、泪腺、甲状腺）中出现，是汞在携带RT1n单倍型的BN中诱发免疫病理的一种特定表现。在另一个品系、抗汞的刘易斯大鼠（RT1l）中则没有这种表现。此外，一种强效接触性致敏剂二硝基氟苯（DNFB），只要发生了强烈致敏，也会在孤立的腺体中诱发局灶性腺炎。用单克隆抗体对BN（Hg）中的局灶性腺炎进行免疫组织化学特征分析表明，T细胞和树突状细胞在早期浸润中占主导，而B细胞则不存在。
