McKirdy H C, Marshall R W, Taylor B A
Department of Surgery, University of Wales College of Medicine, Cardiff, UK.
Digestion. 1993;54(4):200-6. doi: 10.1159/000201038.
Circular muscle strips from the human ileocaecal junction developed myogenic tone (sustained resting tension) in vitro and showed an obvious component of relaxation in response to electrical field stimulation. These features are considered typical of sphincteric muscle because circular muscle strips from terminal ileum 1-2 cm proximal to the junction and from the caecum or ascending colon 1-2 cm distal to the junction developed little or no tone and showed predominantly contractile responses to electrical-field stimulation. In 18 out of 29 specimens, junctional strips showed excitatory responses to adrenaline or noradrenaline. The relaxation of junctional strips was non-adrenergic non-cholinergic (NANC) in nature. Nitric oxide appears to be involved in the NANC relaxation.
来自人回盲交界处的环形肌条在体外产生肌源性张力（持续静息张力），并对电场刺激表现出明显的舒张成分。这些特征被认为是括约肌的典型特征，因为距交界处近端1-2厘米的回肠末端以及距交界处远端1-2厘米的盲肠或升结肠的环形肌条几乎没有或没有产生张力，并且对电场刺激主要表现出收缩反应。在29个标本中的18个中，交界处的肌条对肾上腺素或去甲肾上腺素表现出兴奋反应。交界处肌条的舒张本质上是非肾上腺素能非胆碱能（NANC）的。一氧化氮似乎参与了NANC舒张过程。
