Bozzette S A, McCutchan J A, Spector S A, Wright B, Richman D D
Department of Medicine, University of California, San Diego.
J Infect Dis. 1993 Dec;168(6):1374-9. doi: 10.1093/infdis/168.6.1374.
The association between isolation of the syncytium-inducing (SI) phenotype of human immunodeficiency virus (HIV) and unfavorable clinical and immune status was evaluated in a cross-sectional study. Data on HIV phenotype were available for 341 of 878 persons entering clinical trials of antiretroviral therapies. Patients with SI virus were demographically similar to those with non-SI (NSI) virus but were more likely to have a diagnosis of AIDS and detectable circulating HIV p24 antigen. Patients with SI virus also had a lower CD4+ cell count and a higher serum level of beta 2-microglobulin. The association between phenotype and present status was explained statistically by CD4+ cell count. Phenotype, serum level of beta 2-microglobulin, and the presence of detectable p24 antigen were all independent predictors of present CD4+ cell count. The likelihood of finding SI virus increased with unfavorable virologic and immunologic parameters and varied with the amount of prior antiretroviral therapy.
在一项横断面研究中，评估了人类免疫缺陷病毒（HIV）的合胞体诱导（SI）表型分离与不良临床和免疫状态之间的关联。在878名进入抗逆转录病毒疗法临床试验的患者中，有341人的HIV表型数据可用。SI病毒患者在人口统计学上与非SI（NSI）病毒患者相似，但更有可能被诊断为艾滋病且可检测到循环HIV p24抗原。SI病毒患者的CD4 +细胞计数也较低，β2-微球蛋白血清水平较高。CD4 +细胞计数在统计学上解释了表型与当前状态之间的关联。表型、β2-微球蛋白血清水平和可检测到的p24抗原的存在都是当前CD4 +细胞计数的独立预测因素。发现SI病毒的可能性随着病毒学和免疫学参数的不利而增加，并随先前抗逆转录病毒治疗的量而变化。
