Urnovitz H B, Clerici M, Shearer G M, Gottfried T D, Robison D J, Lutwick L I, Montagnier L, Landers D V
Calypte Biomedical Corporation, Berkeley, CA 94710.
Lancet. 1993 Dec 11;342(8885):1458-9. doi: 10.1016/0140-6736(93)92934-l.
7 individuals who were negative for HIV-1 antibody in a licensed serum enzyme immunoassay (EIA) were positive in a urine EIA and western blot (WB). Follow-up in individuals by use of a cell-mediated immune response showed 1 positive and 1 negative for HIV-1 peptide reactivity. In a second study, 4 out of 5 subjects positive by urine EIA and indeterminate or negative by serum WB were HIV-1 peptide positive in the cell-mediated immune test. Comparison of cell-mediated responses with urine antibody responses may help to resolve discrepant HIV-1 results.
