中枢神经系统和自主神经系统与APUD系统（及其APUD瘤）的联系。

Central and autonomic nervous system links to the APUD system (and their APUDomas).

作者信息

Baylis B W, Tranmer B I, Ohtaki M

机构信息

Department of Medicine, University of Calgary, Alberta, Canada.

出版信息

Semin Surg Oncol. 1993 Sep-Oct;9(5):387-93. doi: 10.1002/ssu.2980090507.

DOI:10.1002/ssu.2980090507

PMID:7902607

Abstract

The concept of the APUD system and the APUDomas associated with it has evolved significantly since Pearse's description in the 1960s. Part of this evolution has been an understanding of the relationships between the APUD system and the central and autonomic nervous systems. The APUD system now referred to as the diffuse neuroendocrine system, can be linked to the central nervous system and autonomic nervous system by genetics, embryology, cellular characteristics, anatomy, interaction of the systems, and the immune system. Awareness of these relationships may enable clinicians to better understand APUDomas and lead to better methods of detection of these tumours and their treatment.

摘要

自20世纪60年代皮尔西（Pearse）首次描述以来，APUD系统及其相关的APUD瘤的概念已经有了显著发展。这种发展的一部分是对APUD系统与中枢神经系统和自主神经系统之间关系的认识。APUD系统现在被称为弥散神经内分泌系统，它可以通过遗传学、胚胎学、细胞特征、解剖学、系统间相互作用以及免疫系统与中枢神经系统和自主神经系统联系起来。认识到这些关系可能使临床医生能够更好地理解APUD瘤，并找到更好的检测这些肿瘤及其治疗的方法。