Ofner Michael, Walach Harald
Institute of Pathophysiology and Immunology, Medical University of Graz, Graz, Austria.
Department of Pediatric Gastroenterology, Poznan University of Medical Sciences, Poznań, Poland.
Front Physiol. 2020 Sep 23;11:547526. doi: 10.3389/fphys.2020.547526. eCollection 2020.
We describe a potentially new physiological reflex path that has so far been neglected but which could be used for a novel therapeutic approach: The vegetative receptor-vascular reflex. This is a physiological response that starts from the connective tissue and influences the whole organism. We cross-fertilized various research areas with each other.
The matrix or the connective tissue forms a passive reservoir of substrate for the growth and development of cells, and functions as the primordial communication system of all living systems. It contains a continuous network of cells, such as fibroblasts, along with protein bundles made up of collagen that support electrical exchange through piezoelectric effects. This archaic vegetative system surrounds all cells, including neurons, and can thus be viewed as the primordial coordinating system in every organism. It is very likely the basis for a reflex which we describe here for the first time: the vegetative receptor vascular reflex. We also indicate some potential practical applications and test procedures.
The vegetative receptor vascular reflex describes the pathway from stimuli that originate in the connective tissue or the extracellular matrix toward organ systems. They might be chemical in nature or electrical via piezo-electric effects stimulating nerve endings, and thus can influence higher order processes such as regeneration or healing of tissue. Thus, this reflex lends itself to a novel therapeutic approach via certain types of manipulation of the connective tissue.
我们描述了一条迄今为止被忽视但可用于一种新治疗方法的潜在新生理反射路径：植物性受体 - 血管反射。这是一种从结缔组织起始并影响整个机体的生理反应。我们将各个研究领域相互交叉融合。
基质或结缔组织形成细胞生长和发育的被动底物储存库，并作为所有生命系统的原始通信系统发挥作用。它包含一个连续的细胞网络，如成纤维细胞，以及由胶原蛋白组成的蛋白束，这些蛋白束通过压电效应支持电交换。这个古老的植物性系统包围着所有细胞，包括神经元，因此可被视为每个生物体中的原始协调系统。它很可能是我们首次在此描述的一种反射的基础：植物性受体血管反射。我们还指出了一些潜在的实际应用和测试程序。
植物性受体血管反射描述了从结缔组织或细胞外基质产生的刺激通向器官系统的途径。这些刺激可能本质上是化学性的，或者通过刺激神经末梢的压电效应是电性的，从而能够影响诸如组织再生或愈合等更高层次的过程。因此，这种反射通过对结缔组织的某些类型操作适用于一种新的治疗方法。
