Zittoun R, Cadiou M, Facquet-Danis J, Zittoun J, Bilski-Pasquier G
Pathol Biol (Paris). 1976 Sep;24(7):469-75.
134 cases of acute leukemia in adults were classified according a "double blind" cytological diagnosis, a cytochemical study, and lysozyme assay. Each type has distinct characters, allowing a good nosological definition. The histochemical methods, as well as lysozyme assay are usually unnecessary, particularly in well differenciated myeloblastic, promyelocytic or myelo-monocytic acute leukemia. They are, on the contrary, frequently useful in poorly differenciated myeloblastic or monoblastic leukemia. But, they cannot help to solve every problem in cytological diagnosis: there are still 10% of undifferenciated acute leukemia, the lymphoblastic acute leukemia are not clearly defined and 4% of cases of acute leukemia have atypical characters leading to difficulties in cytological classification. The need for new methods and markers is emphasized.
134例成人急性白血病根据“双盲”细胞学诊断、细胞化学研究和溶菌酶测定进行分类。每种类型都有独特的特征,有助于做出良好的疾病分类定义。组织化学方法以及溶菌酶测定通常没有必要,特别是在分化良好的急性粒细胞白血病、早幼粒细胞白血病或粒-单核细胞白血病中。相反,它们在分化不良的急性粒细胞白血病或单核细胞白血病中经常有用。但是,它们无助于解决细胞学诊断中的所有问题:仍有10%的未分化急性白血病,急性淋巴细胞白血病尚无明确定义,4%的急性白血病病例具有非典型特征,导致细胞学分类困难。强调需要新的方法和标志物。