新药在英国一个地区的市场渗透率：对全科医生和管理人员的影响。
Market penetration of new drugs in one United Kingdom region: implications for general practitioners and administrators.
作者信息
McGavock H, Webb C H, Johnston G D, Milligan E
机构信息
Department of Therapeutics and Pharmacology, Queen's University of Belfast.
出版信息
BMJ. 1993 Oct 30;307(6912):1118-20. doi: 10.1136/bmj.307.6912.1118.
OBJECTIVE
To determine the use of new drugs in one United Kingdom region.
DESIGN
Examination of data on prescribing of angiotensin converting enzyme inhibitors, new broad spectrum antibiotics, and H2 receptor antagonists. Calculation of number of defined daily doses prescribed each month.
SETTING
All general practices in Northern Ireland.
MAIN OUTCOME MEASURES
Drug use index and market share of each drug.
RESULTS
During 1988-91 prescribing of angiotensin converting enzyme inhibitors increased by 126%, of H2 receptor antagonists by 46%, and of new antibiotics by 207%. The first drug on the market usually retained the largest market share. Use of oral antibiotics increased threefold irrespective of the reporting policy of the general practitioners' local laboratory.
CONCLUSIONS
The increase in prescribing of these drugs seems to be greater than can be accounted for by an increase in patients with specific indications for these drugs. This suggests that the profession has not instituted effective checks to ensure that the legitimate promotion of new products does not lead to inappropriate and wasteful use.
目的
确定英国一个地区新药的使用情况。
设计
检查关于血管紧张素转换酶抑制剂、新型广谱抗生素和H2受体拮抗剂处方的数据。计算每月规定日剂量的处方数量。
地点
北爱尔兰所有的普通诊所。
主要观察指标
每种药物的药物使用指数和市场份额。
结果
1988 - 1991年间，血管紧张素转换酶抑制剂的处方量增加了126%，H2受体拮抗剂增加了46%，新型抗生素增加了207%。市场上的第一种药物通常保持最大的市场份额。无论全科医生当地实验室的报告政策如何，口服抗生素的使用量都增加了两倍。
结论
这些药物处方量的增加似乎超过了因这些药物特定适应症患者数量增加所能解释的范围。这表明该行业尚未建立有效的检查机制，以确保新产品的合理推广不会导致不当和浪费性使用。
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