Lijnen P, Petrov V, Tjandramaga T, Verbesselt R, Amery A
Department of Pathophysiology, University of Leuven (K.U. Leuven), Belgium.
Methods Find Exp Clin Pharmacol. 1993 Sep;15(7):483-90.
The effect of carmoxirole, a presynaptic dopamine (DA2) receptor agonist, on blood pressure, plasma catecholamines, renin-aldosterone and atrial natriuretic peptide and the intracellular concentration and transmembrane fluxes of Na+ and K+, in erythrocytes and platelets was studied in 24 normal men, using a double-blind, parallel study design. After a run-in period of 1 week, the subjects were treated with either placebo (n = 8) or 0.5 mg carmoxirole (n = 16) once daily for 1 week. Blood pressure and heart rate were not changed during carmoxirole administration in these normal men. Surprisingly, no significant effect of carmoxirole was found on the circulating plasma concentration of noradrenaline, adrenaline or dopamine. Other hormones such as renin, aldosterone and atrial natriuretic peptide were also not changed during carmoxirole administration. No significant effect of carmoxirole could be demonstrated on the intracellular concentration of Na+, K+, Mg2+ and Ca2+ and on the transmembrane fluxes of Na+ and K+ in erythrocytes and platelets. In the carmoxirole-treated subjects (n = 16), 6 subjects reported spontaneously adverse events such as syncope, dizziness and vomiting tendencies and/or fatigue.
采用双盲平行研究设计，在24名正常男性中研究了突触前多巴胺（DA2）受体激动剂卡莫昔罗对血压、血浆儿茶酚胺、肾素 - 醛固酮和心房利钠肽以及红细胞和血小板中Na +和K +的细胞内浓度和跨膜通量的影响。经过1周的导入期后，受试者被给予安慰剂（n = 8）或0.5 mg卡莫昔罗（n = 16），每日一次，持续1周。在这些正常男性服用卡莫昔罗期间，血压和心率没有变化。令人惊讶的是，未发现卡莫昔罗对去甲肾上腺素、肾上腺素或多巴胺的循环血浆浓度有显著影响。在服用卡莫昔罗期间，肾素、醛固酮和心房利钠肽等其他激素也没有变化。未证明卡莫昔罗对红细胞和血小板中Na +、K +、Mg2 +和Ca2 +的细胞内浓度以及Na +和K +的跨膜通量有显著影响。在接受卡莫昔罗治疗的受试者（n = 16）中，有6名受试者自发报告了不良事件，如晕厥、头晕和呕吐倾向和/或疲劳。
