Lijnen P
Department of Pathophysiology, University of Leuven, Belgium.
Methods Find Exp Clin Pharmacol. 1992 Apr;14(3):211-7.
The effects of naftopidil on the intracellular concentration and transmembrane fluxes of Na+ and K+ in erythrocytes and on the intracellular Na+, K+ and free cytosolic Ca2+ concentration in platelets were studied in twenty-four normal male subjects, using a double-blind study design. After a run-in period on placebo for 1 week, the subjects were treated with either placebo (n = 8) or naftopidil 25 mg (n = 8) or 50 mg (n = 8) once a day for 4 weeks. Intraerythrocyte Na+ concentration and the erythrocyte anion carrier were decreased during naftopidil administration. No significant effect of naftopidil could be demonstrated on ouabain-sensitive Na+ efflux, bumetanide-sensitive Na+ efflux, ouabain, bumetanide-resistant Na+ and K+ efflux and Na+, Li(+)-countertransport activity in red blood cells or on the intraerythrocyte K+ and Mg2+ concentration. The free cytosolic Ca2+ and Na+ concentration in platelets was also decreased during naftopidil administration while no effect of naftopidil was found on the intracellular K+ and Mg2+ concentration in platelets.
采用双盲研究设计，在24名正常男性受试者中研究了萘哌地尔对红细胞内Na⁺和K⁺的细胞内浓度及跨膜通量以及血小板内Na⁺、K⁺和游离胞质Ca²⁺浓度的影响。在接受1周安慰剂导入期后，受试者被随机分为三组，分别接受安慰剂（n = 8）、25 mg萘哌地尔（n = 8）或50 mg萘哌地尔（n = 8）治疗，每日1次，共4周。服用萘哌地尔期间，红细胞内Na⁺浓度和红细胞阴离子载体减少。萘哌地尔对红细胞中哇巴因敏感的Na⁺外流、布美他尼敏感的Na⁺外流、哇巴因、布美他尼耐药的Na⁺和K⁺外流以及Na⁺、Li⁺逆向转运活性或红细胞内K⁺和Mg²⁺浓度均无显著影响。服用萘哌地尔期间，血小板内游离胞质Ca²⁺和Na⁺浓度也降低，而萘哌地尔对血小板内K⁺和Mg²⁺浓度无影响。
