多巴胺D1受体家族激动剂SK&F38393、SK&F77434和SK&F82958对大鼠的运动活动有不同影响。
Dopamine D1 receptor family agonists, SK&F38393, SK&F77434, and SK&F82958, differentially affect locomotor activities in rats.
作者信息
Meyer M E, Shults J M
机构信息
Department of Psychology, University of Florida, Gainesville 32611.
出版信息
Pharmacol Biochem Behav. 1993 Oct;46(2):269-74. doi: 10.1016/0091-3057(93)90352-t.
Dopamine D1 receptor family agonists, 2,3,4,5,-tetrahydro-7,8-dihydroxy-1phenyl-1H-3-benzazepine (SK&F38393), 3-allyl-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (SK&F77434), and 3-allyl-6-chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazep ine (SK&F82958), were compared for their behavioral effects on horizontal movement time, rearing time, stereotypy time, and thigmotaxis time. All agonists resulted in biphasic effects with attenuation followed by potentiation (0.01-10.0 mg/kg, SC). While SK&F38393 did not potentiate horizontal movement and rearing times, and had minor effects on thigmotaxis, SK&F77434 and SK&F82958 potentiated horizontal movement and rearing behaviors and attenuated thigmotaxis. The results were discussed in terms of the binding characteristics and current receptor theory.
比较了多巴胺D1受体家族激动剂2,3,4,5-四氢-7,8-二羟基-1-苯基-1H-3-苯并氮杂卓（SK&F38393）、3-烯丙基-2,3,4,5-四氢-7,8-二羟基-1-苯基-1H-3-苯并氮杂卓（SK&F77434）和3-烯丙基-6-氯-2,3,4,5-四氢-7,8-二羟基-1-苯基-1H-3-苯并氮杂卓（SK&F82958）对水平移动时间、竖毛时间、刻板行为时间和趋触性时间的行为学影响。所有激动剂均产生双相效应，先减弱后增强（0.01 - 10.0 mg/kg，皮下注射）。虽然SK&F38393没有增强水平移动和竖毛时间，对趋触性影响较小，但SK&F77434和SK&F82958增强了水平移动和竖毛行为，并减弱了趋触性。根据结合特性和当前受体理论对结果进行了讨论。
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