肌肉注射噻嗪铵和吸入组胺对一秒用力吸气量的影响。

Effect of intramuscular administration of thiazinamium and inhaled histamine on forced inspiratory volume in 1 s.

作者信息

Gimeno F, van Altena R

机构信息

Asthma Clinic, Beatrixoord Hospital, Haren, The Netherlands.

出版信息

Respiration. 1993;60(4):227-31. doi: 10.1159/000196204.

DOI:10.1159/000196204

PMID:7903469

Abstract

Twenty-one patients with symptoms suggestive of asthma were evaluated clinically by allergy skin tests, pulmonary function, and histamine inhalation challenge. In addition to the forced expiratory manoeuvres (FEV1), forced inspiratory manoeuvres (FIV1), were performed before and after intramuscular administration of thiazinamium (Multergan), a bronchodilator with markedly anticholinergic properties. The same lung function parameters (FEV1 and FIV1) were obtained before and after histamine inhalation challenge. The response after bronchodilatation in litres of FEV1 2.42 +/- 1.12 to 3.27 +/- 0.98 (mean +/- SD) was much larger than in FIV1 3.44 +/- 1.35 to 4.05 +/- 1.14 (p < 0.05). After histamine inhalation the observed decrease in FEV1 (2.65 +/- 0.99 to 2.06 +/- 0.89) was not so great as in FIV1 (3.76 +/- 1.09 to 2.90 +/- 1.15) (p < 0.02). These results suggest that patients often have more difficulty with inspiration rather than expiration.

摘要

对21名有哮喘症状的患者进行了临床评估，采用了过敏皮肤试验、肺功能测试和组胺吸入激发试验。除了用力呼气动作（FEV1）外，在肌肉注射噻嗪铵（Multergan，一种具有明显抗胆碱能特性的支气管扩张剂）前后还进行了用力吸气动作（FIV1）。在组胺吸入激发试验前后获取相同的肺功能参数（FEV1和FIV1）。支气管扩张后，FEV1的反应从2.42±1.12升增加到3.27±0.98升（平均值±标准差），比FIV1从3.44±1.35升增加到4.05±1.14升的反应大得多（p<0.05）。组胺吸入后，观察到的FEV1下降（从2.65±0.99降至2.06±0.89）不如FIV1下降（从3.76±1.09降至2.90±1.15）明显（p<0.02）。这些结果表明，患者通常吸气比呼气更困难。