男同性恋人群队列中从HIV血清转化到CD4+淋巴细胞终点及艾滋病的时间差异。
Differences in time from HIV seroconversion to CD4+ lymphocyte end-points and AIDS in cohorts of homosexual men.
作者信息
Veugelers P J, Schechter M T, Tindall B, Moss A R, Page K A, Craib K J, Cooper D A, Coutinho R A, Charlebois E, Winkelstein W
机构信息
Municipal Health Service, Department of Public Health, Amsterdam, The Netherlands.
出版信息
AIDS. 1993 Oct;7(10):1325-9. doi: 10.1097/00002030-199310000-00004.
OBJECTIVE
To evaluate the decline in CD4+ counts in relation to the incidence of AIDS in different cohorts of homosexual men and to quantify possible consequences of laboratory variation in CD4+ measurement.
METHODS
Our study includes 403 men with well documented dates of HIV seroconversion originating from five cohort studies among homosexual men. Differences in time from HIV seroconversion to the first CD4+ count dropping < 500 or 200 x 10(6)/l and to AIDS were evaluated using Kaplan-Meier survival analyses.
RESULTS
We found considerable differences between cohorts in CD4+ depletion, but not in the incidence of AIDS (1987 definition).
CONCLUSIONS
Variation in CD4+ depletion appears to be mainly the result of laboratory differences. Policy recommendations on a basis of CD4+ counts probably requires a calibration of measurement. The 1993 AIDS case definition leads to a site-specific shortening of the incubation time, which complicates the study of the natural history of HIV infection and of trends in the AIDS epidemic.
目的
评估不同队列同性恋男性中CD4 +细胞计数下降与艾滋病发病率的关系，并量化CD4 +测量中实验室差异可能产生的后果。
方法
我们的研究纳入了403名有明确记录的HIV血清转化日期的男性，他们来自五项同性恋男性队列研究。使用Kaplan-Meier生存分析评估从HIV血清转化到首次CD4 +细胞计数降至<500或200×10⁶/L以及发展为艾滋病的时间差异。
结果
我们发现不同队列在CD4 +细胞耗竭方面存在显著差异，但在艾滋病发病率（1987年定义）方面没有差异。
结论
CD4 +细胞耗竭的差异似乎主要是实验室差异的结果。基于CD4 +细胞计数的政策建议可能需要对测量进行校准。1993年艾滋病病例定义导致特定部位的潜伏期缩短，这使得对HIV感染自然史和艾滋病流行趋势的研究变得复杂。
Zotero 插件