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[肾上腺素能、胆碱能和多巴胺能制剂对家兔高压神经综合征形成的影响]

[The effect of adren-, cholin- and dopaminergic preparations on the formation of the high-pressure nervous syndrome in rabbits].

作者信息

Sledkov A Iu, Bednarskiĭ K V

出版信息

Fiziol Zh Im I M Sechenova. 1993 Sep;79(9):26-33.

PMID:7903583
Abstract

Behaviour and the EEG responses to electric intracranial stimulation of the frontal cortex, mesencephalic RF, dorsal hippocampus and caudate nucleus were studied in hyperbaric experiments in rabbits. Thresholds of the stimulation for all the areas were decreased at 41 ATA, the thresholds progressively decreasing at 71 and 101 ATA. Preliminary administration of various pharmacological agents activating and inhibiting different neurotransmitter systems, altered the regularity of the EEG changes and behaviour. Dopaminergic agents suppressed some signs of the nervous high-pressure syndrome.

摘要

在兔高压实验中,研究了额叶皮质、中脑网状结构、背侧海马和尾状核的电颅内刺激所引发的行为及脑电图反应。在41个绝对大气压(ATA)时,所有区域的刺激阈值均降低,在71和101个ATA时阈值逐渐降低。预先给予激活和抑制不同神经递质系统的各种药理剂,改变了脑电图变化和行为的规律性。多巴胺能药剂抑制了神经高压综合征的一些症状。

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