白细胞介素13是一种B细胞刺激因子。
Interleukin 13 is a B cell stimulating factor.
作者信息
Defrance T, Carayon P, Billian G, Guillemot J C, Minty A, Caput D, Ferrara P
机构信息
Unité d'Immunologie et Stratégie Vaccinale, Institut Pasteur de Lyon, France.
出版信息
J Exp Med. 1994 Jan 1;179(1):135-43. doi: 10.1084/jem.179.1.135.
Abstract
The recently cloned human interleukin 13 (IL-13) is a novel cytokine expressed in activated T cells that has been shown to inhibit inflammatory cytokine production by lipopolysaccharide-activated monocytes. The protein encoded by the IL-13 cDNA is the human homologue of a mouse Th2-product called P600. Here, we show that IL-13 acts at different stages of the B cell maturation pathway: (a) it enhances the expression of CD23/Fc epsilon RII and class II MHC antigens on resting B cells; (b) it stimulates B cell proliferation in combination with anti-Ig and anti-CD40 antibodies; and (c) it induces IgE synthesis. Thus, the spectrum of the biological activities of IL-13 on B cells largely overlaps that previously ascribed to IL-4. The present observations suggest that IL-13 may be an important factor, in addition to IL-4, in the development of allergic diseases.
摘要
最近克隆出的人白细胞介素13（IL-13）是一种在活化T细胞中表达的新型细胞因子，已证明它能抑制脂多糖激活的单核细胞产生炎性细胞因子。IL-13 cDNA编码的蛋白质是一种名为P600的小鼠Th2产物的人类同源物。在此，我们表明IL-13作用于B细胞成熟途径的不同阶段：（a）它增强静息B细胞上CD23/FcεRII和II类MHC抗原的表达；（b）它与抗Ig和抗CD40抗体联合刺激B细胞增殖；（c）它诱导IgE合成。因此，IL-13对B细胞的生物活性谱在很大程度上与先前归因于IL-4的谱重叠。目前的观察结果表明，除IL-4外，IL-13可能是过敏性疾病发展中的一个重要因素。
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