Shimada E, Urakawa T, Ueda T
Department of Surgery, Kobe Rosai Hospital.
Nihon Shokakibyo Gakkai Zasshi. 1993 Nov;90(11):2889-94.
The coexpression of EGFR and c-erbB-2 protein was examined immunohistochemically in a total of 62 freshly frozen specimens of colorectal cancer, and correlations between the coexpression of both receptors and their clinicopathological variables were analyzed. Positive staining of both receptors was found in 21 cases, and it was related to the degree of lymphatic or vascular invasion of cancer cell, the synchronous metastasis to liver or lung, and the most advanced stage (Dukes' D). Moreover, the incidence of the distant metastasis including metachronous metastasis to other organs such as liver, lung or peritoneum were significantly higher in the positive cases of both receptors. These results suggest that the coexpression of EGFR and c-erbB-2 protein may be related to the distant metastasis of colorectal cancer.
采用免疫组织化学方法检测了62例新鲜冷冻的结直肠癌标本中EGFR和c-erbB-2蛋白的共表达情况，并分析了两种受体共表达与其临床病理变量之间的相关性。在21例病例中发现两种受体均呈阳性染色，且与癌细胞的淋巴或血管浸润程度、肝或肺的同步转移以及最晚期（杜克分期D期）有关。此外，两种受体均为阳性的病例中，包括肝、肺或腹膜等其他器官的异时转移在内的远处转移发生率显著更高。这些结果表明，EGFR和c-erbB-2蛋白的共表达可能与结直肠癌的远处转移有关。
