Kluftinger A M, Robinson B W, Quenville N F, Finley R J, Davis N L
Department of Surgery, University of British Columbia, Vancouver, Canada.
Surg Oncol. 1992 Feb;1(1):97-105. doi: 10.1016/0960-7404(92)90062-p.
Both epidermal growth factor receptor (EGFr) and the oncogene product of c-erbB2 have been shown to be expressed by human malignancies, and in some cases to relate to clinical outcomes. This study investigates the correlation between the presence of these receptor proteins and known prognostic indicators of colorectal cancer. Indirect immunoperoxidase staining of 32 freshly frozen surgical specimens revealed an overall expression of EGFr and c-erbB2 of 43% and 38%, respectively. A significantly higher rate of EGFr expression was found in tumours of more advanced stage (Dukes C and D), poor differentiation and those exhibiting vascular and lymphatic invasion. The presence of the c-erbB2 protein did not correlate with any of these variables. Expression of these molecules appeared to be independent and positive staining for both receptors occurred in only 19% of cases. EGFr may play a future role as a prognostic tool in colorectal cancer.
表皮生长因子受体（EGFr）和c-erbB2癌基因产物均已被证明在人类恶性肿瘤中表达，并且在某些情况下与临床结果相关。本研究调查了这些受体蛋白的存在与已知的结直肠癌预后指标之间的相关性。对32份新鲜冷冻手术标本进行间接免疫过氧化物酶染色，结果显示EGFr和c-erbB2的总体表达率分别为43%和38%。在更晚期（杜克C期和D期）、低分化以及表现出血管和淋巴浸润的肿瘤中，发现EGFr表达率显著更高。c-erbB2蛋白的存在与这些变量均无相关性。这些分子的表达似乎相互独立，两种受体均呈阳性染色的情况仅占19%。EGFr可能在未来作为结直肠癌的一种预后工具发挥作用。
