Moran M J, Santos J L, Fontanellas A, Sepulveda P, Enriquez de Salamanca R
Porphyria Unit, Hospital Universitario Doce de Octubre, Madrid, Spain.
J Dermatol Sci. 1993 Oct;6(2):155-8. doi: 10.1016/0923-1811(93)90006-b.
To assess the clinical utility of saliva samples, serum, urine and saliva porphyrin concentration were fluorometrically measured in 31 patients with porphyria cutanea tarda. In comparison with normal values, porphyrin mean levels were 20-fold increased in serum and urine but only 3-fold in saliva. Saliva porphyrin concentration exhibited significant but weak correlations with porphyrin levels in serum (r = 0.69) and urine (r = 0.67). However, saliva porphyrins were not more closely correlated with protein-unbound serum porphyrins (r = 0.57). This finding suggests that saliva porphyrin concentration does not simply correspond to the filtered free fraction of serum porphyrins. Nevertheless, measurement of saliva porphyrins could represent a valuable non-invasive alternative to serum porphyrins in the monitoring of patients with porphyria cutanea tarda.
为评估唾液样本的临床实用性，对31例迟发性皮肤卟啉病患者的血清、尿液和唾液中的卟啉浓度进行了荧光测定。与正常值相比，血清和尿液中的卟啉平均水平升高了20倍，而唾液中仅升高了3倍。唾液卟啉浓度与血清（r = 0.69）和尿液（r = 0.67）中的卟啉水平呈显著但较弱的相关性。然而，唾液卟啉与非蛋白结合血清卟啉的相关性并不更强（r = 0.57）。这一发现表明，唾液卟啉浓度并非简单地对应于血清卟啉的滤过游离部分。尽管如此，在迟发性皮肤卟啉病患者的监测中，唾液卟啉的测定可能是血清卟啉测定的一种有价值的非侵入性替代方法。
