Ishikawa A
Department of Neurology, Nishiojiya National Sanatorium.
Nihon Rinsho. 1993 Nov;51(11):2947-51.
The diagnosis and treatment of juvenile parkinsonism (JP) is described. There was a high incidence of familial JP (58.1%), and its inheritance pattern was usually an autosomal recessive type. The patients with JP presented with improvement of parkinsonian symptoms following sleep and dystonic posture of the feet as specific signs. The tremor was a fine postural, and impairment of postural reflex was prominent. In the treatment of JP, it is important to control the wearing-off phenomenon and the dopa-induced choreic dyskinesia usually occurring in the extremities. A small dose of levodopa with decarboxylase inhibitor has to be carefully administered several times a day. The clinical course of JP is very slowly progressive compared with that of Parkinson's disease.
本文描述了青少年帕金森病（JP）的诊断与治疗。家族性JP的发病率较高（58.1%），其遗传模式通常为常染色体隐性遗传型。JP患者表现出睡眠后帕金森症状改善以及足部肌张力障碍姿势等特异性体征。震颤为精细姿势性震颤，姿势反射障碍较为突出。在JP的治疗中，控制通常出现在四肢的剂末现象和多巴诱导的舞蹈症异动症很重要。必须谨慎地每天多次给予小剂量左旋多巴与脱羧酶抑制剂。与帕金森病相比，JP的临床病程进展非常缓慢。
