Takubo H
Department of Neurology, Juntendo University School of Medicine.
Nihon Rinsho. 1997 Jan;55(1):101-5.
The treatment and prognosis of juvenile parkinsonism(JP) with onset under the age of 40 years is described. The patients with JP responded better to L-dopa and more gradual progression of symptoms, but, developed dopa-induced dyskinesias and motor fluctuations earlier and more frequently than Parkinson's disease patients. In order to control the dyskinesias and motor fluctuations, a small dose of L-dopa has to be administered several times a day with the combination of dopamine-receptor agonists. As a result of the increased life expectancy with L-dopa treatment the mean duration of the disease has increased in Parkinson's disease and JP, however, mean age at death in JP was still under 60.
本文描述了40岁以下发病的青少年帕金森病（JP）的治疗与预后情况。JP患者对左旋多巴反应较好，症状进展较为缓慢，但与帕金森病患者相比，更早且更频繁地出现左旋多巴诱导的运动障碍和运动波动。为了控制运动障碍和运动波动，必须每日多次给予小剂量左旋多巴，并联合多巴胺受体激动剂。由于左旋多巴治疗使预期寿命增加，帕金森病和JP的疾病平均病程均有所延长，然而，JP患者的平均死亡年龄仍低于60岁。
