[神经递质-受体成像]

[Neurotransmitter-receptor-imaging].

作者信息

Cordes M, Hierholzer J, Nikolai-Beyer K

机构信息

Strahlenklinik, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin.

出版信息

Radiologe. 1993 Nov;33(11):612-9.

PMID:7904078

Abstract

The importance of neuroreceptor imaging in vivo using single photon emission tomography (SPECT) and positron emission tomography (PET) has increased enormously. The principal neurotransmitters, such as dopamine, GABA/benzodiazepine, acetylcholine, and serotonin, are presented with reference to anatomical, biochemical, and physiological features. The main radioligands for SPECT and PET are introduced, and methodological characteristics of both PET and SPECT are summarized. Finally, the results of neurotransmitter receptor imaging obtained so far will be discussed.

摘要

使用单光子发射断层扫描（SPECT）和正电子发射断层扫描（PET）进行体内神经受体成像的重要性已大幅提高。文中参照解剖学、生物化学和生理学特征介绍了多巴胺、γ-氨基丁酸/苯二氮䓬、乙酰胆碱和血清素等主要神经递质。介绍了SPECT和PET的主要放射性配体，并总结了PET和SPECT的方法学特点。最后，将讨论迄今为止获得的神经递质受体成像结果。