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Reduction of RI alpha subunit of cAMP-dependent protein kinase expression induces growth inhibition of human mammary epithelial cells transformed by TGF-alpha, c-Ha-ras, and c-erbB-2 genes.

作者信息

Ciardiello F, Tortora G, Pepe S, Bianco C, Baldassarre G, Ruggiero A, Bianco C, Selvam M P, Bianco A R

机构信息

Cattedra di Oncologia Medica, II Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli, Italy.

出版信息

Ann N Y Acad Sci. 1993 Nov 30;698:102-7. doi: 10.1111/j.1749-6632.1993.tb17194.x.

DOI:10.1111/j.1749-6632.1993.tb17194.x
PMID:7904135
Abstract
摘要

相似文献

1
Reduction of RI alpha subunit of cAMP-dependent protein kinase expression induces growth inhibition of human mammary epithelial cells transformed by TGF-alpha, c-Ha-ras, and c-erbB-2 genes.
Ann N Y Acad Sci. 1993 Nov 30;698:102-7. doi: 10.1111/j.1749-6632.1993.tb17194.x.
2
Down-regulation of RI alpha subunit of cAMP-dependent protein kinase induces growth inhibition of human mammary epithelial cells transformed by c-Ha-ras and c-erbB-2 proto-oncogenes.环磷酸腺苷依赖性蛋白激酶RIα亚基的下调诱导由c-Ha-ras和c-erbB-2原癌基因转化的人乳腺上皮细胞的生长抑制。
Int J Cancer. 1993 Feb 1;53(3):438-43. doi: 10.1002/ijc.2910530315.
3
Transforming growth factor-alpha expression is enhanced in human mammary epithelial cells transformed by an activated c-Ha-ras protooncogene but not by the c-neu protooncogene, and overexpression of the transforming growth factor-alpha complementary DNA leads to transformation.在被激活的c-Ha-ras原癌基因转化的人乳腺上皮细胞中，转化生长因子-α的表达增强，但在被c-neu原癌基因转化的细胞中则不然，并且转化生长因子-α互补DNA的过表达会导致细胞转化。
Cell Growth Differ. 1990 Sep;1(9):407-20.
4
Additive effects of c-erbB-2, c-Ha-ras, and transforming growth factor-alpha genes on in vitro transformation of human mammary epithelial cells.c-erbB-2、c-Ha-ras和转化生长因子-α基因对人乳腺上皮细胞体外转化的累加效应。
Mol Carcinog. 1992;6(1):43-52. doi: 10.1002/mc.2940060108.
5
Differentiation of HL-60 leukemia by type I regulatory subunit antisense oligodeoxynucleotide of cAMP-dependent protein kinase.环磷酸腺苷依赖性蛋白激酶I型调节亚基反义寡脱氧核苷酸诱导HL-60白血病细胞分化
Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):2011-5. doi: 10.1073/pnas.88.5.2011.
6
8-Chloro-cAMP inhibits transforming growth factor alpha transformation of mammary epithelial cells by restoration of the normal mRNA patterns for cAMP-dependent protein kinase regulatory subunit isoforms which show disruption upon transformation.8-氯-cAMP通过恢复cAMP依赖性蛋白激酶调节亚基同工型的正常mRNA模式来抑制乳腺上皮细胞的转化生长因子α转化，这些同工型在转化时会出现破坏。
J Biol Chem. 1990 Jan 15;265(2):1016-20.
7
Transformation of mouse mammary epithelial cells with the Ha-ras but not with the neu oncogene results in a gene dosage-dependent increase in transforming growth factor-alpha production.用Ha-ras而非neu癌基因转化小鼠乳腺上皮细胞，会导致转化生长因子-α的产生呈基因剂量依赖性增加。
FEBS Lett. 1989 Jul 3;250(2):474-8. doi: 10.1016/0014-5793(89)80779-3.
8
Site-selective 8-chloroadenosine 3',5'-cyclic monophosphate inhibits transformation and transforming growth factor alpha production in Ki-ras-transformed rat fibroblasts.
FEBS Lett. 1989 Jan 2;242(2):363-7. doi: 10.1016/0014-5793(89)80502-2.
9
Resistance to taxanes is induced by c-erbB-2 overexpression in human MCF-10A mammary epithelial cells and is blocked by combined treatment with an antisense oligonucleotide targeting type I protein kinase A.在人MCF-10A乳腺上皮细胞中，c-erbB-2过表达可诱导对紫杉烷的耐药性，而靶向I型蛋白激酶A的反义寡核苷酸联合治疗可阻断这种耐药性。
Int J Cancer. 2000 Mar 1;85(5):710-5. doi: 10.1002/(sici)1097-0215(20000301)85:5<710::aid-ijc18>3.0.co;2-4.
10
Amphiregulin as an autocrine growth factor for c-Ha-ras- and c-erbB-2-transformed human mammary epithelial cells.双调蛋白作为c-Ha-ras和c-erbB-2转化的人乳腺上皮细胞的自分泌生长因子。
Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2790-4. doi: 10.1073/pnas.91.7.2790.

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The cAMP analogs have potent anti-proliferative effects on medullary thyroid cancer cell lines.环磷酸腺苷（cAMP）类似物对甲状腺髓样癌细胞系具有强大的抗增殖作用。
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