Urry R L, Carrell D T, Starr N T, Snow B W, Middleton R G
Division of Urology, University of Utah School of Medicine, Salt Lake City.
J Urol. 1994 Feb;151(2):381-3. doi: 10.1016/s0022-5347(17)34954-6.
Infertility in patients with a history of cryptorchidism is usually the result of oligo-asthenospermia. In this study we analyzed the incidence of antisperm antibodies in infertility patients with a history of cryptorchidism, general infertility patients and donors of known fertility. Of the cryptorchid patients 66% tested positive for antisperm antibodies compared to 2.6% of the control group of infertile patients and 2.8% of the donors of known fertility. Sperm progressive motility was significantly (p < 0.05) decreased in the cryptorchid patients testing positive for antisperm antibodies compared to those testing negative for antisperm antibodies, and compared to both control groups. Of the patients treated for cryptorchidism by orchiopexy 52% were positive for antisperm antibodies, and the mean patient age at orchiopexy was significantly (p < 0.01) higher in the positive antibody group (14.2 +/- 1.2 years old) than the negative antibody group (8.6 +/- 0.8 years old). While decreased sperm concentration, motility and morphology are usually the primary causes of infertility in patients with a history of cryptorchidism, it appears that the presence of antisperm antibodies is also increased in these patients, which may contribute to reduced fertility.
有隐睾病史的患者不育通常是少弱精子症的结果。在本研究中，我们分析了有隐睾病史的不育患者、一般不育患者和已知有生育能力的供者中抗精子抗体的发生率。隐睾患者中66%抗精子抗体检测呈阳性，相比之下，不育对照组患者中这一比例为2.6%，已知有生育能力的供者中为2.8%。与抗精子抗体检测呈阴性的隐睾患者相比，以及与两个对照组相比，抗精子抗体检测呈阳性的隐睾患者精子前向运动能力显著降低（p<0.05）。在接受睾丸固定术治疗隐睾的患者中，52%抗精子抗体呈阳性，抗体阳性组患者接受睾丸固定术时的平均年龄（14.2±1.2岁）显著高于抗体阴性组（8.6±0.8岁）（p<0.01）。虽然精子浓度、活力和形态降低通常是有隐睾病史患者不育的主要原因，但这些患者中抗精子抗体的存在似乎也有所增加，这可能导致生育力下降。
