抗精子抗体与男性不育

Antisperm antibodies and male infertility.

作者信息

Upadhyaya M, Hibbard B M, Walker S M

出版信息

Br J Urol. 1984 Oct;56(5):531-6. doi: 10.1111/j.1464-410x.1984.tb06272.x.

DOI:10.1111/j.1464-410x.1984.tb06272.x

Abstract

Two hundred males attending a fertility clinic and 65 men who had fathered one or more children were screened for sperm antibodies using sperm agglutination and immobilisation tests. The incidence of sperm antibodies was significantly higher in the former group. Agglutinin and immobilisin were not related to sperm concentration, morphology, ejaculate volume, seminal plasma zinc, magnesium, acid phosphatase and fructose. However, sperm motility and viability were significantly reduced in the presence of sperm antibodies. There appeared to be no relationship between the presence of antisperm antibodies and Mycoplasma, aerobic or anaerobic organisms. There was a positive correlation between agglutinating and immobilising antibodies in serum and seminal plasma. This study suggests that sperm antibodies at a significant titre may lower male fertility.

摘要

对200名前往生育诊所的男性以及65名育有一个或多个孩子的男性，采用精子凝集试验和制动试验筛查精子抗体。前一组中精子抗体的发生率显著更高。凝集素和制动素与精子浓度、形态、射精量、精浆锌、镁、酸性磷酸酶和果糖均无关联。然而，在存在精子抗体的情况下，精子活力和存活率显著降低。抗精子抗体的存在与支原体、需氧或厌氧生物之间似乎没有关系。血清和精浆中的凝集抗体与制动抗体之间呈正相关。本研究表明，具有显著滴度的精子抗体可能会降低男性生育能力。