Hasegawa H, Watanabe M, Arisawa Y, Teramoto T, Kodaira S, Kitajima M
Department of Surgery, School of Medicine, Keio University, Tokyo.
Jpn J Clin Oncol. 1993 Dec;23(6):336-41.
A comparative immunohistochemical study was performed to analyse the expression of cancer-associated carbohydrate antigens by primary and metastatic lesions of colon cancer. We used monoclonal antibodies which reacted with Lea, Lex and Tn as well as their sialylated derivatives. Twenty-one primary lesions in patients without metastasis and 26 primary and metastatic lesions in patients with liver metastasis were studied. Sialyl Lea was expressed by 57% of the primary lesions of patients without metastasis, 65% of the primary lesions of patients with metastasis and 73% of their liver metastases. Sialyl Lex was expressed by 60% of the primary lesions of patients with and without metastasis as well as by approximately 80% of the liver metastases. Sialyl Lea and sialyl Lex showed strong expressions in the liver metastases, significantly greater than in the primary lesions. The findings indicate the increased expressions of sialyl Lea and sialyl Lex to be correlated with liver metastasis of colorectal cancer.
进行了一项比较性免疫组织化学研究，以分析结肠癌原发灶和转移灶中癌症相关碳水化合物抗原的表达情况。我们使用了与Lea、Lex和Tn及其唾液酸化衍生物发生反应的单克隆抗体。研究了21例无转移患者的原发灶以及26例有肝转移患者的原发灶和转移灶。唾液酸化Lea在无转移患者的57%原发灶、有转移患者的65%原发灶及其73%的肝转移灶中表达。唾液酸化Lex在有转移和无转移患者的60%原发灶以及约80%的肝转移灶中表达。唾液酸化Lea和唾液酸化Lex在肝转移灶中呈强表达，显著高于原发灶。这些发现表明唾液酸化Lea和唾液酸化Lex的表达增加与结直肠癌的肝转移相关。
