Ikeda Y, Mori M, Kajiyama K, Haraguchi Y, Sasaki O, Sugimachi K
Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Surg Oncol. 1996 Jul;62(3):171-6. doi: 10.1002/(SICI)1096-9098(199607)62:3<171::AID-JSO5>3.0.CO;2-4.
Sialyl Lewis Tn(STN), sialyl Lewis a(CA-9-9), sialyl Lewis a-b-(DU-PAN-2), and sialyl Lewis x(SLX) antigens were immunohistochemically examined in the primary tumor and metastatic lymph nodes in 35 patients with advanced gastric cancer. STN, CA-19-9, DU-PAN-2, and SLX were expressed in 91%, 60%, 31%, and 60% in the primary lesion, and 77%, 54%, 22%, and 51% in the metastatic lesion, respectively. In only four cases, (11%) were all four antigens expressed in both the primary and metastatic lesions. Three antigens were expressed in 49% of primary lesions and in 20% of metastatic lesions. Compared with expression in primary lesions, increased, unchanged and decreased expressions in metastatic lesions were noted in 23%, 37%, and 40% for STN, 20%, 40%, and 40% for CA-19-9, 17%, 57%, and 26% for DU-PAN-2, and 26%, 31%, and 43% for SLX, respectively. These results indicate that the tumor in the primary and metastatic lesions has a heterogeneous expression of sialyl-related antigens. However, metastases cannot be predicted based upon the expression of these antigens.
对35例晚期胃癌患者的原发性肿瘤和转移淋巴结进行免疫组织化学检查，检测唾液酸化路易斯Tn（STN）、唾液酸化路易斯a（CA-9-9）、唾液酸化路易斯a-b（DU-PAN-2）和唾液酸化路易斯x（SLX）抗原。STN、CA-19-9、DU-PAN-2和SLX在原发性病变中的表达率分别为91%、60%、31%和60%，在转移病变中的表达率分别为77%、54%、22%和51%。仅4例（11%）原发性和转移病变中均表达全部四种抗原。三种抗原在49%的原发性病变和20%的转移病变中表达。与原发性病变中的表达相比，STN在转移病变中的表达增加、不变和降低的比例分别为23%、37%和40%，CA-19-9分别为20%、40%和40%，DU-PAN-2分别为17%、57%和26%，SLX分别为26%、31%和43%。这些结果表明，原发性和转移病变中的肿瘤具有唾液酸相关抗原的异质性表达。然而，无法根据这些抗原的表达来预测转移情况。
