Likhvantsev V V, Smirnova V I, Grebenchikov O A, Moroz V V, Subbotin V V
Khirurgiia (Mosk). 1993 Sep(9):19-26.
The authors analyse the early components of somatosensory evoked potentials (SSEP) during anesthesia in prolonged and traumatic operations on the abdominal organs (gastrectomy, hemihepatectomy, pancreatoduodenal resection, etc.). A total of 69 patients were examined, among them 32 underwent operations under conditions of classical NLA, 16 with the narcotic analgetics replaced by moradol, and 21 under modified NLA with dalargin. The results of the study and analysis of literature data allow monitoring of the early components of somatosensory evoked potentials to be considered a highly sensitive test for appraising the depth and adequacy of the modern methods of general anesthesia and to be recommended for use, at least in particularly difficult and venturesome operations. It is shown that most significant in the discussed plan is not the absolute value, but changes of the N19-P23 amplitude in the stages of the operation. Increase of the studied SSEP component by 20% and more in relation to the basal level (SSEP amplitude in the patient after adequate preanesthesia) is evidence of insufficient analgesia. Change of N19-P23 latency is less demonstrative. Monitoring of the early components (N19-P23) of SSEP showed that to ensure effective analgesia in prolonged concurrent and combined operations, if the NLA method is chosen, administration of fentanyl in a dose of no less than 12 micrograms/kg/hour is necessary. It is shown that replacement of narcotic analgesics, within the limits of the conducted NLA, by moradol, an agent of the group of agonists-antagonists is poorly effective.(ABSTRACT TRUNCATED AT 250 WORDS)
作者分析了腹部器官长时间创伤性手术(胃切除术、半肝切除术、胰十二指肠切除术等)麻醉期间体感诱发电位(SSEP)的早期成分。共检查了69例患者,其中32例在经典非吸入麻醉(NLA)条件下接受手术,16例用吗多明替代麻醉性镇痛药,21例在改良NLA下使用达明。研究结果及文献数据分析表明,监测体感诱发电位的早期成分可被视为评估现代全身麻醉方法深度和充分性的高度敏感测试,至少在特别困难和风险大的手术中推荐使用。结果显示,在所讨论的方案中,最重要的不是绝对值,而是手术各阶段N19 - P23波幅的变化。与基础水平(充分麻醉前患者的SSEP波幅)相比,所研究的SSEP成分增加20%及以上表明镇痛不足。N19 - P23潜伏期的变化指示性较小。对SSEP早期成分(N19 - P23)的监测表明,在长时间联合手术中,若选择NLA方法,为确保有效镇痛,芬太尼剂量不少于12微克/千克/小时是必要的。结果显示,在进行的NLA范围内,用激动剂 - 拮抗剂组药物吗多明替代麻醉性镇痛药效果不佳。(摘要截选至250字)