Meizerov E E, Blinov A V, Reshetniak V K
NII Traditional Methods of Therapy, Department of Health and Medical Industry RF.
Anesteziol Reanimatol. 1996 Jul-Aug(4):10-3.
The central mechanisms of analgesic action of phentanyl and moradol are compared using analysis of changes in the early and late components of somatosensory evoked potentials (SSEP) of the brain in normal volunteers in response to pain stimulation. Phentanyl and moradol differently affect the changes in the early components of SSEP: phentanyl reduces their amplitude, whereas moradol increases it. Both drugs similarly influenced changes in the late components of SSEP. Specific effects of the drugs on the sensory and psychoemotional components of pain perception by man are discussed.
通过分析正常志愿者大脑体感诱发电位（SSEP）早期和晚期成分在疼痛刺激后的变化，比较了芬太尼和吗啡的镇痛作用中心机制。芬太尼和吗啡对SSEP早期成分的变化有不同影响：芬太尼降低其振幅，而吗啡则增加其振幅。两种药物对SSEP晚期成分的变化影响相似。讨论了药物对人类疼痛感知的感觉和心理情绪成分的特定作用。
