Rahemtulla A, Shahinian A, Kundig T, Zinkernagel R, Mak T W
Amgen Institute, Toronto, Ontario, Canada.
Philos Trans R Soc Lond B Biol Sci. 1993 Oct 29;342(1299):57-8. doi: 10.1098/rstb.1993.0135.
CD4 is a co-receptor required for T cell helper functions. A mouse strain without CD4 expression has been generated. These animals, surprisingly have a normal CTL response and reduced, but not absent, humoral responses. A new population of MHC class II restricted CD4-CD8-TcR alpha beta+ T cells has emerged which possess helper function potential. These findings have important implications on disease situations where CD4 cells are decreased or absent.
CD4是T细胞辅助功能所需的共受体。已经培育出一种不表达CD4的小鼠品系。令人惊讶的是，这些动物具有正常的细胞毒性T淋巴细胞（CTL）反应，其体液反应有所降低但并非完全缺失。已出现一群新的主要组织相容性复合体（MHC）II类限制性CD4-CD8-T细胞受体αβ+ T细胞，它们具有辅助功能潜力。这些发现对于CD4细胞减少或缺失的疾病情况具有重要意义。
