多巴胺受体激动剂阿扑吗啡对正常受试者阴茎勃起的影响。

Effect of apomorphine, a dopamine receptor agonist, on penile tumescence in normal subjects.

作者信息

Lal S, Ackman D, Thavundayil J X, Kiely M E, Etienne P

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1984;8(4-6):695-9. doi: 10.1016/0278-5846(84)90040-x.

Abstract

Apomorphine HCl (Apo) (0.25, 0.5 or 0.75 mg sc), a dopamine (DA) receptor agonist, induced penile erections (PEs) (monitored by mercury strain gauges and continuous recording on paper strip charts) in 7 out of 9 normal subjects and placebo in 1 of these 9 (p less than 0.05). Apo-induced PEs recurred in each of the 6 subjects retested. Benztropine (2 mg iv) had no effect on Apo-induced penile tumescence (PT). These data suggest (a) DA mechanisms play a role in normal erectile function (b) DA-mediated PT is not modulated by cholinergic systems (c) evaluation of the erectile response to Apo may provide a simple ancillary test to the investigation of impotence and a way of identifying a subpopulation of impotent subjects with impaired DA function who may respond to long-acting DA agents (d) Apo-induced PT may provide a novel way of studying DA function in man.

摘要

盐酸阿扑吗啡（Apo）（皮下注射0.25、0.5或0.75毫克），一种多巴胺（DA）受体激动剂，在9名正常受试者中有7名诱发出阴茎勃起（PEs）（通过水银应变仪监测并在纸带图表上连续记录），9名受试者中有1名对安慰剂有反应（p小于0.05）。在重新测试的6名受试者中，Apo诱发的PEs均再次出现。苯海索（静脉注射2毫克）对Apo诱发的阴茎肿胀（PT）没有影响。这些数据表明：（a）多巴胺机制在正常勃起功能中起作用；（b）多巴胺介导的阴茎肿胀不受胆碱能系统调节；（c）评估对Apo的勃起反应可能为阳痿研究提供一种简单的辅助测试方法，以及一种识别多巴胺功能受损的阳痿亚组受试者的方法，这些受试者可能对长效多巴胺制剂有反应；（d）Apo诱发的阴茎肿胀可能为研究人体多巴胺功能提供一种新方法。