Identification of a new DNA polymorphism tightly linked to DQ-alpha locus.
作者信息
Gasparini P, Bonizzato A, Totaro A, Zelante L
机构信息
Servizio di Genetica Medica, IRCCS, Ospedale CSS, San Giovanni Rotondo, Italia.
出版信息
Exp Clin Immunogenet. 1993;10(3):176-8.
PMID:7904457
Abstract
Utilizing Alu-polymerase chain reaction and single-strand conformation polymorphism technologies a new DNA restriction fragment length polymorphism was detected on a cosmid clone located on chromosome 6p21. An accurate analysis of allele frequency was carried out on a large series of unrelated individuals. Furthermore a detailed linkage analysis in several large pedigrees showed this new polymorphism to be tightly linked to the HLA-DQ alpha locus.
摘要
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