Meetze W H, Shenoy V, Martin G, Musy P, Neu J
Department of Pediatrics, University of Florida, Gainesville 32610.
Biol Neonate. 1993;64(6):368-75. doi: 10.1159/000244013.
The ontogeny of small intestinal glutaminase (GA) and glutamine synthetase (GS) was studied with relation to the maternal administration of dexamethasone (DEX). Pregnant Sprague-Dawley rats were administered 0.2 mg/kg of DEX or saline twice daily on days 19 and 20 of gestation. Activity of GA did not increase from the fetus to the 10-day-old rat; however, GS activity increased 7-fold. DEX induced doubling of GA activity and mRNA, but only a slight increase is GS activity and mRNA was observed in the fetus. GA and GS activities appear to be regulated by different mechanisms.
研究了小肠谷氨酰胺酶（GA）和谷氨酰胺合成酶（GS）的个体发生与地塞米松（DEX）母体给药的关系。在妊娠第19天和第20天，给怀孕的Sprague-Dawley大鼠每日两次注射0.2mg/kg的DEX或生理盐水。从胎儿到10日龄大鼠，GA活性没有增加；然而，GS活性增加了7倍。DEX使胎儿的GA活性和mRNA增加了一倍，但GS活性和mRNA仅略有增加。GA和GS的活性似乎受不同机制调节。
